Polynucleotides (Plinest) at The Medical Skin Clinic
Regenerate your skin at a cellular level
The next generation of regenerative aesthetics. Polynucleotides repair damaged skin, calm inflammation and stimulate fibroblasts — the cells that make collagen — for genuinely healthier skin.
£350
from per session
2–3
Sessions in a typical course
What is Polynucleotides?
Regeneration, not just hydration
Polynucleotides (Plinest) are purified, naturally derived DNA fragments that work as cell-signalling molecules. Injected into the skin, they switch on repair processes: stimulating fibroblasts, improving elasticity and calming inflammation.
They are particularly effective for tired, thinning or sun-damaged skin — and for the delicate under-eye area where fillers aren't always appropriate.
- Stimulates fibroblasts and natural collagen production
- Excellent for under-eyes, face, neck and hair-thinning areas
- Course of 2–3 sessions, 3–4 weeks apart
- Natural improvement in skin quality over 4–12 weeks
The science
How polynucleotides renew skin
Repair
Purified polynucleotide fragments signal damaged cells to begin repair, reducing inflammation and oxidative stress in the tissue.
Regenerate
Fibroblasts are activated to produce new collagen and elastin, gradually thickening and strengthening the skin from within.
Rehydrate
The treatment restores the skin's water-binding capacity, improving tone, texture and luminosity over the following weeks.
Real patient results
Measured, natural — never overdone
Every plan begins with an honest consultation and is reviewed at a complimentary follow-up. Individual results vary — which is exactly why we never template a treatment.
4–12 wk
Progressive improvement window
3–4 wk
Between course sessions
6–9 mo
Typical maintenance interval
Treatment areas
Where Polynucleotides can help
Under-eye
Dark circles, crepey skin
Face
Skin quality and elasticity
Neck & décolletage
Thin, sun-damaged skin
Scalp
Support for thinning hair
Transparent pricing
Polynucleotides pricing
All prices are transparent and agreed before any treatment begins. Every treatment is performed by a registered medical practitioner.
Single session
£350
One polynucleotide / PRP treatment, precisely injected by a medical practitioner.
Book thisCourse of three
£975
The clinically recommended initial course for lasting regeneration.
Book thisConsultation
£25
Honest assessment with a nurse prescriber — redeemable against your treatment.
Book thisWhy choose us
Medical-grade care, every time
CQC registered
Fully regulated by the Care Quality Commission — rated “Good”. Your safety comes before everything.
Doctors & nurses only
Every treatment is performed by registered medical professionals — never beauticians.
137 five-star reviews
A 5.0 score across 137 verified Google reviews — read them before you book.
Minimal downtime
Most treatments take under an hour, and most patients return to their day immediately.
FAQ
Questions, answered honestly
Can't find your answer? Call us on 01638 476423 — our team will be glad to help.
Ready to talk about Polynucleotides?
Begin with an honest, no-obligation consultation with a registered medical practitioner.
Learn more in the Education Station
Related skin conditions
CQC Registered
Rated "Good" at inspection
5.0 on Google
137 patient reviews
Medical practitioners only
Doctors, nurse prescribers & dentists
Honest consultations
No obligation to proceed